It's time for an appointment with the former staff of Princeton-Plainsboro Teaching Hospital.

It's tough to sell a TV drama where the main character declares, "humanity is overrated," but the Fox medical series House proved likeability isn't everything.

For eight seasons, Dr. Gregory House (brought to life by British thesp Hugh Laurie) clashed with administrators, doctors, and even his patients when they got in the way of a tricky diagnosis. Modeled along the lines of the brilliant but acerbic detective Sherlock Holmes, House investigated diseases as if they were crimes, accompanied by his "Watson," Dr. James Wilson (Robert Sean Leonard), and a diagnostic team of trusty subordinates.

As the show reached its conclusion in 2012, Laurie summed up his complicated character by posing questions to Entertainment Weekly: "Is it worth using bad means for good ends? Can an action be good if its motive is bad? Or if its motive is not intentionally good? What is a soul? Is there a God? If there isn't, what defines a friend, and what will you do for him? We didn't always express these questions well, by any means, but we tried, and a large number of people around the world seemed to respond to the effort. I am so damn proud of that."

It's been 20 years since the series debuted. Read on to learn what's become of the House cast since the hospital closed its doors.